PRoMPT BOLUS

This page provides a quick guide to the PRoMPT BOLUS study

Aims

1. To determine if fluid resuscitation with balanced fluids will improve clinical outcomes compared to fluid resuscitation with 0.9% saline in paediatric septic shock under usual clinical conditions
2. To monitor the safety of balanced fluids versus 0.9% saline in paediatric septic shock

Intervention

PlasmaLyte vs 0.9% Saline

Eligibility

Inclusion

• Age: 2 months to 16 years
• Suspected septic shock
  • Requiring IV antibiotics
  • Requiring fluid bolus
• With a plan to administer a second fluid bolus

Exclusion

• Patient has received >40ml/kg of fluid
• Clinician judgement that enrolment is unsafe
  • Suspected brain herniation
  • Known hyperkalaemia, hypercalcaemia
  • Known hepatic, renal failure
  • Known metabolic or mitochondrial disease
• Known pregnancy
• Known prisoner
• Known fluid allergy

What you need to do:

1. Collect a study pack from the research trolley
2. Fill in the enrolment form
3. Provide information pamphlet to the parents (we have ethics approval for delayed consent)
4. Open randomisation envelope and prescribe the study fluids on the paperwork provided in the study pack
5. Return completed enrolment form to the research trolley
6. Fill in patient details in the enrolment log book
7. Study team will get informed consent and complete all remaining paperwork

Further Questions

• Dr Anna Lithgow; paediatrician (This email address is being protected from spambots. You need JavaScript enabled to view it.
• Megan Duck; Research Coordinator (This email address is being protected from spambots. You need JavaScript enabled to view it.) 28608
• Hanna Bjoern; Research nurse (hanna.bjoernThis email address is being protected from spambots. You need JavaScript enabled to view it.) 27969
• This email address is being protected from spambots. You need JavaScript enabled to view it. 0460034800
• Further information from the Murdoch Children's Research Institute