ARISE Fluids

ARISE Fluids Study

Australasian Resuscitation in Sepsis Evaluation: Fluids or Vasopressors in

Emergency Department Sepsis

A randomised controlled trial

 

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AIMS

  • P In patients with septic shock presenting to the emergency department
  • I does an early vasopressor/fluid-sparing resuscitation strategy
  • C compared to a fluid unrestricted/later vasopressor regimen
  • O Improve hospital-free survival and functional outcome?

Inclusion Criteria

Exclusion Criteria
  • Clinically suspected infection
  • SBP <90mmHg or MAP<65mmHg despite >=1000ml cumulative total bolus of IV fluid administered over not more than 60 minutes (including pre-hospital fluids)
  • Venous or arterial lactate >2.0mmol/L
  • At least one dose of an intravenous antimicrobial has been commenced

 
  • Age <18 years
  • Confirmed or suspected pregnancy
  • Transfer from another acute healthcare facility
  • Hypotension suspected due to a non-sepsis cause
  • >2L total IV fluid administered (including prehospital fluids but excluding drugs or flushes)
  • More than 6 hours has elapsed since ED arrival or more than 2 hours since last inclusion criterion met
  • Treating clinician believes that one or both of the treatment regimens is not suitable for the patient, or the study protocol cannot be delivered e.g. limitation of care, requirement for immediate surgery
  • Death is considered imminent or inevitable
  • Underlying disease which makes survival to 90 days unlikely
  • Inability to follow up e.g. unstable accommodation, overseas visitor
  • Previous enrolment in the ARISE FLUIDS trial

 

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What you need to do:

  • Any patient that meets inclusion criteria either:
    • Randomise the patient or
    • contact the research team on 28608 to assist
  • To Randomise a patient:
  • Log onto www.arisefluids.org  User Name: rdpharise Password: AriseArise
    • Randomise the patient
    • Print randomisation result
    • Grab the relevant study arm pack from research draw in resus (dependent on which arm the patient was randomised to)
    • Attach intervention arm laminate to IV pole
    • Put handover form in notes
    • Text the research team with patients name, HRN and study ID number
    • Patient to stay on allocated arm for
      • Minimum 6 hours
      • Maximum 24 hours if in ED/ICU

Further Questions

  • Prinicipal Investigator: Dr Sandra Brownlea This email address is being protected from spambots. You need JavaScript enabled to view it.
    • Megan Duck; Research Coordinator (This email address is being protected from spambots. You need JavaScript enabled to view it.) 28608
    • Hanna Bjoern; Research nurse (hanna.bjoernThis email address is being protected from spambots. You need JavaScript enabled to view it.) 27969
    • This email address is being protected from spambots. You need JavaScript enabled to view it. 0460034800